PharmacyCodes



Dofetilidum [Inn-Latin] en es it fr

Dofetilidum [Inn-Latin] Brand names, Dofetilidum [Inn-Latin] Analogs

Dofetilidum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Dofetilidum [Inn-Latin] Chemical_Formula

C19H27N3O5S2

Dofetilidum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic2/dofetilide.htm

Dofetilidum [Inn-Latin] fda sheet

Dofetilidum_[Inn-Latin] FDA

Dofetilidum [Inn-Latin] msds (material safety sheet)

Dofetilidum [Inn-Latin] Synthesis Reference

No information avaliable

Dofetilidum [Inn-Latin] Molecular Weight

441.567 g/mol

Dofetilidum [Inn-Latin] Melting Point

No information avaliable

Dofetilidum [Inn-Latin] H2O Solubility

No information avaliable

Dofetilidum [Inn-Latin] State

Solid

Dofetilidum [Inn-Latin] LogP

4.574

Dofetilidum [Inn-Latin] Dosage Forms

Capsule

Dofetilidum [Inn-Latin] Indication

For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm

Dofetilidum [Inn-Latin] Pharmacology

Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm. Dofetilide increases the monophasic action potential duration in a predictable, concentration-dependent manner, primarily due to delayed repolarization. At concentrations covering several orders of magnitude, Dofetilide blocks only IKr with no relevant block of the other repolarizing potassium currents (e.g., IKs, IK1). At clinically relevant concentrations, Dofetilide has no effect on sodium channels (associated with Class I effect), adrenergic alpha-receptors, or adrenergic beta-receptors.

Dofetilidum [Inn-Latin] Absorption

>90%

Dofetilidum [Inn-Latin] side effects and Toxicity

No information avaliable

Dofetilidum [Inn-Latin] Patient Information

No information avaliable

Dofetilidum [Inn-Latin] Organisms Affected

Humans and other mammals